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This selectivity profile is what distinguishes FOXO4-DRI from broader cytotoxic agents and makes it the primary peptide tool for selective senescent cell elimination in the cellular senescence research field

The risk was slightly higher than in the general population in the entire cohort and in those on TNF alpha inhibitors, but the differences were not statistically significant, and the overall absolute incidence was quite low

Last reviewed: June 10, 2026 Last updated: June 10, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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Paraskevi L, Antigoni S, Kleanthi G